| 摘要 |
<p>Compounds of the formula (I): <IMAGE> (I) having pharmacological activities similar to those of natural prostaglandins wherein: n is 0 to 5; X is CO, CS or CH2; Y is -CH2-CH2-; or, when n is 1 to 5, -CH=CH- or -C 3BOND C-; R1 is either CH2NR5R6, wherein R5 and R6 are separately hydrogen or C1-6 alkyl, or R5 is hydrogen and R6 is (CH2)mCO2R19 wherein m is 0 to 4 and R19 is optionally substituted C1-6 alkyl or benzyl, optionally substituted in the phenyl ring by chlorine or bromine atoms or by nitro or CF3 groups; or R5 and R6 are both the same (CH2)mCO2R19 as hereinbefore defined; or C(NH2)=NOH; or C(OR7)=NH2+B- wherein R7 is C1-6 alkyl and B- is a salting ion; or CH2NHR8, wherein R8 is SO2R19, COR19 or CZNHR9 and R19 is as hereinbefore defined, R9 is hydrogen or C1-6 alkyl and Z is oxygen or sulphur; or CZNH2 wherein Z is as hereinbefore defined: R2 is hydrogen or C1-4 alkyl; R3 is C1-9 alkyl, C5-8 cycloalkyl or C5-8 cycloalkyl -C1-6 alkyl; or R2 and R3 taken with the carbon atom to which they are joined represent a C5-8 cycloalkyl group; and R4 is hydrogen or C1-6 alkyl; and salts thereof; with the provisos (i) that when X is CH2 then Y must be -CH2-CH2-, and (ii) when R1 is CH2NR5R6 or CH2NHR8 then Y must be -CH2-CH2-, pharmaceutical compositions containing them and processes for their preparation.</p> |
