| 摘要 |
1,226,247. Pyridine derivatives. ZAIDAN HOJIN DOHMYAKUKOHKA KENKYU SHOREIKAI. 25 March, 1969 [8 April, 1968 (2); 14 Sept., 1968], No. 15525/69. Heading C2C. Novel, therapeutic compounds I wherein R 1 is H or alkyl, R 2 is H, alkyl, allyl, aryl, aralkyl, furfuryl, picolyl or pyridyl, R 3 is H or alkyl, and R 4 signifies H, alkyl, CO 2 R 5 (R 5 is alkyl) or CONR 6 R 7 (R 6 and R 7 signify H or alkyl) and R 1 and R 2 and R 3 and R 4 can together form a divalent alkylene chain which may be interrupted by a heteroatom, are obtained: (a) by the interaction of a compound II with an isocyanate, R 2 NCO (R 2 may not be H); (b) by converting a compound II into an ester III utilizing standard methods and thereafter reacting the ester with a base, NHR 1 R 2 (Ar signifies an aryl group, e.g. pH; or (c) by converting a compound II into the corresponding chlorocarbonic ester utilizing phosgene and subsequently treating the ester with a base, NHR 1 R 2 . |
