| 摘要 |
Cellulose granules suitable for use in tableting, having good flow and good binding characteristics, said granules having a particle size as follows: less than five percent (5%) on a 35 mesh (Tyler) screen; less than thirty percent (30%) through a 100 mesh screen; and less than five percent (5%) through a 200 mesh screen, as measured on a Ro-Tap TM (Tyler) sifter using a 25 gram sample and with a sieving time of 25 minutes, said cellulose granules consisting essentially of compacted, granulated, and screened cellulose consisting essentially of cellulose fibers having an average length on their largest dimension of between about 20 and about 55 microns, especially between about 30 and about 40 microns, and process of making same by compacting, granulating, and classifying, preferably in a Chilsonator TM ; admixtures of said granules with pharmaceutical excipients or binders, especially dibasic calcium phosphate.
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