PROCESS FOR PREPARATION OF MAYTANSINOL DERIVATIVES

摘要

Maytansinol was produced by fermn. with Nocardia ATCC 31281 followed by sepn. of maytansinol from the mixed broth of maytansinol, maytanacine and maytansinol propionate. Thus, a preculture of Nocardia No. C-15003(IFO 13726) was inoculated into a pH 7 medium composed of dextrin 5, corn steep liquor 3, polypeptone 0.1 and CaCO3 0.5% and incubated at 28≦̸C for 90 hr.