| 摘要 |
<p>The invention relates to a new penicillanic and cephalosporanic derivatives of the general formula (I)
<CHEM>
wherein R is H or -OH; R1 is a carbohydrate selected from the class of hexoses comprising glucose, galactose, glucose acetals, glucose chetals, galactose acetals and galactose chetals, and R2 is
<CHEM>
R3 being H or an alkaline or alkaline-earth metal, as well as to the preparation thereof and pharmaceutical compositions containing same.
<??>A process according to the invention comprises the reaction of a compound of the formula
<CHEM>
with a carbohydrate, selected from the class of hexoses, in cyclic form, in an aqueous medium, in the presence of a water-miscible organic solvent, in the presence of a base, the reaction product being optionally transformed into the derivative wherein R1 is a carbohydrate in the linear form by treatment with Lewis' acid or a hydrogen halide acid.
<??>The compounds according to the invention are used in pharmaceutical compositions useful for treatment of infections by gram-positive and gram-negative pathogenous bacteria. </p> |
