Imidazole derivatives, their production and use.

摘要

Novel imidazole derivatives of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="16" wi="40" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>R<Sup>1</Sup> is lower alkyl or, phenyl-C<Sub>1-2</Sub>alkyl which may be substituted with halogen or nitro;</ListItem><ListItem>R<Sup>2</Sup> is lower alkyl, cycloalkyl or, phenyl which may be substituted with halogen, lower alkyl, lower alkoxyl or di (lower alkyl) amino,</ListItem><ListItem>one of R<Sup>3</Sup> and R<Sup>4</Sup> is of the formula: -(CH<Sub>2</Sub>)<Sub>n</Sub>,-COR<Sup>5</Sup> in the formula</ListItem><ListItem>R<Sup>5</Sup> is amino, lower alkoxyl or hydroxyl and n is integer of 0,1 or 2, and the other is hydrogen or halogen; provided that R<Sup>1</Sup> is lower alkyl or phenethyl when R<Sup>3</Sup> is halogen, n is 1 and R' is lower alkoxyl or hydroxyl, and their salts have hypotensive activity.</ListItem></UnorderedLists>