| 摘要 |
<p>(I) Peptides:- n1, n2 = 0 or 1 X = OH, NH2, alkoxy, alkylamino, dialkylamino or hydrazino each R = amino acid residue devoid of alpha-NH2 and COOH gps. at least 1 R having a NH2 gp. Molecule contains at least 1 long-chain alkoxy-carbonyl, alkenyloxycarbonyl or NH2 substit. (II) Acid-addn. salts of (I). Pref. building components are diaminocarboxylic acids; and derived from essential amino acids in L-form. Esp. (I) when n1 = n2 = 0, X = lower alkoxy and alkoxycarbonyl or alkenyloxycarbonyl has 8-20 C. N alpha-Cetyloxycarbonyl-L-lysyl-L-lysine and corr. N alpha-myristyl cpd; N alpha-octyl-oxycarbonyl-L-ornithyl-L-ornithine; N alpha-lauryl-oxycarbonyl-D-(alpha, gamma-diaminobutyryl)-D-(alpha, gamma-diaminobutyric acid). Antimicrobials (against Gram-positive and -negative bacteria, fungi, yeasts); (I) destroyed by proteolytic enzymes, so used as preservatives for orally ingested materials.</p> |
