Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate.

摘要

An antibacterial composition comprising (a) cephaloridine and a 3-substituted propenoate of either of the formula <CHEM> wherein e.g. R<2> and R<3> are hydrocarbon radicals; a terminal hydrogen in R<3> can be replaced by several groups; R<1> is hydrogen or C1-C6 alkyl or dialkylaminoalkyl, n is 3 to 5 and Y is heterocyclic or phenyl optionally substituted with hydroxyl, oxo, carboxyl, or methyl or (b) thienamycin, N-guanyl or N-formimidoyl thienamycin and a compound of formula II. The propenoate compounds prevent nephrotoxicity of the antibiotics. The antibiotic to propenoate weight ratio is from about 1 to 0.1-3.