发明名称 Prodrugs for improved bioavailability of certain DELTA 4-3-ketosteroidal sex hormones
摘要 Transient, orally active thiazolidine type prodrug forms of conventional, natural and synthetic ketosteroidal sex hormones, e.g., of progesterone, testosterone, and the like, are disclosed. The subject compounds can be prepared by known methods, for example, by reacting the corresponding 3-keto or 3,20-diketo steroids with a thiazolidine-forming reagent such as an L-cysteine alkyl ester.
申请公布号 US4268441(A) 申请公布日期 1981.05.19
申请号 US19790057324 申请日期 1979.07.13
申请人 INTERX RESEARCH CORPORATION 发明人 BODOR, NICHOLAS S.;SLOAN, KENNETH B.
分类号 C07J31/00;C07J33/00;(IPC1-7):A61K31/58 主分类号 C07J31/00
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