2- Or 3-imidazolyl-1-isopropyl-4-methyl cyclohexane derivs. - prepd. by reaction of imidazole with halo- or sulphonyloxy-1-isopropyl-4-methyl-cyclohexane

摘要

New imidazole deriv are 2- and 3-(1-imidazolyl) -4- methyl-1-isopropyl-cyclohexane derivs (I), in which the 3 chiral centres have R- or S- configuration, and their racemates, and pharmacologically tolerable salts of these cpds. (I) are inhibitors of thromboxane synthesis, with greater activity than known imidazole derivs. They accordingly modify the thromboxane A2/PGI2 equilibrium in favour of the antiaggregatory, vasodilating PGI2 at the expense of the proaggregatory and vasoconstricting TXA2, and can be used as antithromboembolic agents.