| 摘要 |
<p>NEW MATERIAL:Pyrrolidinoglycosides of formula I (R1 is hydroxyl-protecting group selected from aralkyl, alkoxyalkyl, alkylthioalkyl; R2 is acetal-protecting g roup selected from alkyl, haloalkyl and aralkyl). EXAMPLE:Methyl 3-O-benzyl-2, 4, 6, 7-tetradeoxy-4, 7-epimino-alpha-D-xyloheptopyranoside. USE:Synthetic intermediate of detoxins having an activity of reducing the toxicity of an antibiotic, plastcidin S. PREPARATION:A cyanosulfonate of formula II (X is tosyloxy, mesyloxy) is made to react with sodium borohydride in an inert solvent, preferably a lower alkanol, in the presence of cobalt chloride, nickel chloride or palladium chloride, preferably at room temperature to give the compound of formula I.</p> |
