| 摘要 |
Novel compounds of the formula <IMAGE> wherein A is methylene, ethylene or ethylidene; R1 is -C 3BOND CH or -CH=CH2; R2 is hydrogen or COR wherein R is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, -NR4R5 wherein each of R4 and R5 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms or <IMAGE> wherein R6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; Ra is hydrogen, <IMAGE> alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or <IMAGE> wherein R7 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; and Rb has the same meaning as defined for Ra except Rb is not <IMAGE> and Ra and Rb can be the same or different; with the provisos that when R2 is hydrogen, R1 is -C 3BOND H; when A is ethylidene, R2 is hydrogen; and when Ra is <IMAGE> A is methylene; and pharmaceutically acceptable salts and individual optical isomers thereof.
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