| 摘要 |
<p>PURPOSE:To prepare the titled compound useful as a medicine having extremely excellent antibacterial activity, economically, in an industrial scale, by reacting a cephalosporin analogue or its salt with thiourea. CONSTITUTION:The compound of formula II (R1 is H, etc.; R2 is H, lower alkyl, etc.; R3 is carboxy) is obtained by reacting the cephalosporin analogue of formula I (X is halogen) or its salt with thiourea in a reaction solvent (e.g. water, alcohol, etc.), and if necessary, eliminating the protecting group of R3 by conventional method, and further converting to a proper pharmacologically acceptable salt. The reaction is carried out at room temperature or with heat for 1hr to several days. EFFECT:The protection and deprotection of the 2-position amino group of the thiazolyl group are not necessary.</p> |
