| 摘要 |
<p>Title compds.(I; R1 = amino, protected amino group; R2 = H, lower alkoxy group; R3 = H, carboxyl protecting group; X = O,S, amino group; B = H, hydroxy, amino, mercapto, hydrocarbon group), useful as antibacterial agent, were prepd. by oxidation of intermediate which was obtained from reaction of formylcephem(II) and hydrazine(III). Thus, the mixt. of dimethylsulfoxide 11 ml, methyl-3-formyl-7-thienylacetamido-3-cephem-4-carboxylate 0.915 g and thiosemicarbazide 0.25 g was stirred for 3 hr, shaked with ethylacetate, washed, dehydrated and solvent was removed to give thiosemicarbazone 0.97 g.</p> |
