发明名称 |
Hypolipaemic bis-para-chloro-phenoxy-acetic acid prodn. - from sodium chloro-phenolate prepd. by reaction of chlorophenol with sodium hydroxide with azeotropic removal of water (OE 15.2.80) |
摘要 |
<p>In the prodn. of bis(p-chlorophenoxy)acetic acid (I), (A) a soln. of sodium p-chloro-phenolate is prepd. by reaction of p-chlorophenol with NaOH with azeotropic removal of water in a solvent mixt. of a 3-6C alcohol and a hydrocarbon of b.pt. 80-150 degrees C; (B) reacting the soln. at reflux with a dichloroacetic acid ester; (C) washing pptd. NaCl with water; (D) hydrolysing the reaction mixt. with NaOH with complete removal of the organic solvent by distn.; (E) pptg. (I) by addn. of dil. mineral acid and filtering it off; and (F) purifying the prod. by reprecipitation and/or recrystallisation. (I) is an orally active agent for lowering serum lipid and cholesterol levels. Simple process avoiding the use of metallic sodium or of NaH and giving pure (I) in up to 90% yield. The p-chlorophenol starting material need only be of technical grade.</p> |
申请公布号 |
FR2467839(A1) |
申请公布日期 |
1981.04.30 |
申请号 |
FR19790026256 |
申请日期 |
1979.10.23 |
申请人 |
BERLIN CHEMIE |
发明人 |
ERHARD GORES, HELLMUT JUST, GUNTER ZIEBELL ET SIGRID KINAST |
分类号 |
C07C59/70;(IPC1-7):07C59/64 |
主分类号 |
C07C59/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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