| 摘要 |
A compound corresponding to the following general formula: <IMAGE> wherein R<1> represents C1-C7 alkyl or C5 or C6 cycloalkyl; R<2> represents C1-C7 alkyl; or R<1> and R<2>, together with the nitrogen atom to which they are attached, complete on azamonocyclic ring which may contain at least one further heteroatom and which may be substituted once or twice by phenyl or C1-C4 alkyl; Ar represent pyridyl, trifluoromethylphenyl, biphenylyl, phenyl which may be substituted once or twice by halogen or C1-C4 alkyl, 1- or 2- naphthyl which may be substituted by halogen or C1-C4 alkyl, or C3-C6 cycloalkyl which may be substituted by C1-C4 alkyl or cyclohexyl; and Alk<1> and Alk<2> each independently represents C2-C4 alkylene; or a non- toxic pharmacologically acceptable acid addition salt thereof. Such compounds may be prepared by reacting an appropriate disubstituted acetonitrile with an appropriate haloalkylamine and subsequently hydrolyzing the resulting nitrile using concentrated sulphuric acid. The compounds may be used as anti-arrhythmic agents. |
