Thiophene derivatives, processes for the production thereof and pharmaceutical compositions containing them.

摘要

The invention relates to compounds of the general formula (I) and physiologically acceptable salts, hydrates and bioprecursors thereof in which one of R1 and R2 represents hydrogen, halogen or a C1-4 alkyl group which may be optionally substituted by hydroxy or C1-4 alkoxy, and the other represents the group R4R5NAlk-(R4 and R5 and see inside the description); R3, which may be in either the 2-or 3-position, represents the group -(CH2)nX(CH2)mNH-Z where X represents -CH2-, -O- or -S-; n represents zero, 1 or 2; m represents 2, 3 or 4; and Z represents either the group -@NHR6 or the group (R6, Y, R7 and R8 and R3 see inside the description); with the provisos that where R2 represents the group R4R5NAlK then R3 is in the 2-position; and where R2 represents hydrogen then R3 is in the 3-position. The compounds of formula (I) show pharmacological activity as selective histamine H2-antagonists.