| 摘要 |
<p>NEW MATERIAL:A peptide (salt) of formula I [R<1> is H or acyl; Rb<1> is H, methyl, etc.; R<2> and R<q> are Hs, carboxyls, formula II (Ra<2> is mono-, di-carboxy lower alkyl, etc.; Rb<2> is H or lower alkyl), etc.; R<p> is H, carboxyl (when one of R<2> and R<q> is H, the other is carboxyl etc.), etc.; R<r> is H or amino-protecting group; m is an integer 1-3; n is an integer 0-2; R<2> is H, protected carboxyl, etc. when R<1> is H, t-butoxycarbonyl, etc. and Rb<1> is methyl, m being 2, n being 1; R<2> is H, (protected) carboxyl, etc. when R<1> is lactoyl, and Rb<1> is methyl, m being 2, n being 1, R<p> and R<q> being carboxyls, R<r> being H, etc.]. EXAMPLE:Propionyl-L-Ala-gamma-D-Glu(alpha-OH)-(L)-meso DAP-(L)-GlyOH. USE:An immune response enhancer, an activator for the reticulo-endothelial system, an interferon producer, a juvenilizing agent, a protecting agent against infection, an antitumor agent, etc. PROCESS:A compound (salt) of formula III is reacted with an esterifying agent.</p> |
