| 摘要 |
Title compd. (I) was prepd. by reaction of vincamin in the mixt. of H2O and MeOH(50%), and pyridoxal-5-phosphate at 65≦̸. Thus, 2l MeOH(50%), and 141.75 g (0.4 mol) vincamin in H20 were fed in reactor, stirred and heated to 40≦̸C. The suspended mixt. was reacted with 106.5 g(0.4 mol) pyridoxal-5-phosphate at 105≦̸C. The reactant was extracted with MeOH under reduced pressure, removed impurity and dried to give 223 g I(m.p.; 150≦̸C, yield; 93%).
|
