| 摘要 |
(A) Quinazoline derivs. - (I) R1 and R2 = H, halogen, lower alkyl (C1-C7), lower alkoxy, nitro, CF3, cyano- or lower alkylthio - R5 = H, alkyl (C1-C7), mono-, di- or trihalo lower alkyl, amino lower alkyl, phenyl, phenyl-lower alkyl or aza-cyclo-lower alkyl-lower alkyl - R6 = H, lower alkyl, mono-, di- or trihalo-lower alkyl, amino-loweralkyl or azacyclo-lower alkyl - lower alkyl - or R5 + R6 may form lower alkylene, aza-lower alkylene or N-lower alkyl-aza-lower alkylene; - R7 = H, lower alkyl, cyclo-lower alkyl or cyclo-lower alkyl-lower alkyl; - B = opt. substd. phenyl or opt. substd. pyridyl - (B) 3-Desoxy derivs. and acid addition salts of (I). - The 4-phenylquinazoline derivs. (I) have anti-convulsive- and anorectic activity. The 4-pyridyl quinazoline derivs. (I) have analgesic activity and are esp. suitable as anti-inflammatory agents. The compounds (I) are also intermediates in the synthesis of known benzodiazepine derivs. and beta-oximes of 2-aminobenzophenones and 2-aminobenzoylpyridines which in turn are starting materials in the preparation of known 6-pyridyl- and 5-phenyl 1, 3-dihydro 2H-1, 4-benzodiazepin 2-one 4-oxides.
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