| 发明名称 |
Heterocyclic containing amides as inhibitors of mammalian collagenase |
| 摘要 |
Mammalian collagenase is inhibited by compounds having the formula <IMAGE> wherein R1 is hydrogen, alkanoyl of 2 to 10 carbon atoms or arylcarbonyl; R2 is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, or 4-alkyl-1-piperazinyl; R3 is alkyl of 3 to 8 carbon atoms, cycloalkyl, aryl, or arylalkyl; and n is an integer of 1 to 20.
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| 申请公布号 |
US4263293(A) |
申请公布日期 |
1981.04.21 |
| 申请号 |
US19800154748 |
申请日期 |
1980.05.30 |
| 申请人 |
E. R. SQUIBB & SONS, INC. |
发明人 |
SUNDEEN, JOSEPH E.;DEJNEKA, TAMARA |
| 分类号 |
C07D295/12;C07C51/08;C07C51/09;C07C51/367;C07C51/377;C07C67/00;C07C313/00;C07C323/60;C07C325/00;C07C327/32;C07D295/13;C07D317/28;(IPC1-7):A61K31/53;A61K31/44;C07D295/14 |
主分类号 |
C07D295/12 |
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