| 摘要 |
<p>NEW MATERIAL:Antibiotic SF-1130X3 substance having the following physical and chemical properties. Melting point: 183 deg.C (decomposition); elemental analysis values: C 43.31%, H 5.88%, N 1.71%, O 49.10% (difference); specific rotary power in 1wt% aqueous solution: +154 deg.; soluble in waer and dimethyl sulfoxide, slightly soluble in an alcohol, insoluble in acetone, benzene, etc.; positive in silver nitratecaustic soda test, etc. USE:An inhibitor for glucosidase activity, inhibitor for sucrase activity, inhibitor for increase of blodd sugar, and a remedy and preventive for diabetes, corpulence, adiposis, gastritis, gastirc ulcer, duodenal ulcer, constipation, carious tooth, etc. PROCESS:For example, a strain of an actimonycete (FERM-P 676) capable of producing SF-1130X3 substance is cultivated, preferably by aerated agitaion method of deep part for 2-3 days. The fermentation filtrated is treated with active carbon under neutral conditions to give the desired compound, which is adsorbed, eluted with 50-60wt% water-containing acetone, and subjected to ion exchange resin treatment.</p> |
