| 摘要 |
<p>New salts of indomethacin, naproxen and diclofenac are those with organic bases, pref. diethylamine, triethanolamine or triethylamine. The new salts have improved absorption characteristics when administered orally, rectally and, especially, cutaneously. The salts may be prepd. by dissolving indomethacin, naproxen or diclofenac in an equiv. amt. or an excess of the organic base and precipitating the resulting salt with a suitable solvent such as hexane. Alternatively, the free acid may be dissolved in an organic solvent (e.g. Et2O) and the soln. treated with an excess of the organic base.</p> |
