| 摘要 |
The invention provides polypeptides of formula I, A-B-Gly-D-E I wherein A is Tyr or substituted Tyr, B is -Gly- or -(D)Ala-, D is, for example, Phe or MePhe and E is, for example, -Met-X, -Leu-X, -Nle-X, -Nva-X, -Ile-X, methioninesulhoxide-X, methioninesulphone-X wherein X is -NR'R'' or -OR''' and each of R', R'' and R''' independently signifies hydrogen or alkyl of 1 to 5 carbon atoms, which compounds possess pharmacological activity, for example, analgesic activity.
|
