| 摘要 |
An advantageous diuretic action by excretion of water, sodium and chloride ions, with reduced excretion of potassium ions, is effected by combined administration of a 19-oxygenated steroid compound of the pregnane series of the formula <IMAGE> (I) wherein Ra represents a hydrogen atom, and Rb represents an alpha -oriented lower alkanoylthio group, or Ra and Rb together represent a carbon-carbon bond or an alpha - or beta -oriented methylene radical, R represents a free hydroxymethyl group or a hydroxymethyl group etherified by a lower alkyl or esterified by a lower alkanoyl; or represents a carboxyl group or a lower alkoxycarbonyl group, and R2 represents a hydrogen atom or the acyl radical Ac of a carboxylic acid, as the aldosterone-antagonising component A on the one hand, and, on the other hand, of a conventional diuretic which is unspecific in respect of electrolyte excretion, e.g. a diuretically effective derivative of benzothiadiazine, benzenesulfonamide, phenoxyacetic acid, benzofuran-2-carboxylic acid or 2,3-dihydrobenzofuran-2-carboxylic acid, as component B. The two components A and B can be administered separately or together as an appropriate composition or pharmaceutical preparation.
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