发明名称 |
Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same |
摘要 |
The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: <IMAGE> wherein R1=alkyl (1-4 C); R2=carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same. The novel compounds possess strong anti-inflammatory properties, when applied locally and cause little or systemic, thymolytic, adrenolytic and salt-retaining effects.
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申请公布号 |
US4260605(A) |
申请公布日期 |
1981.04.07 |
申请号 |
US19800111941 |
申请日期 |
1980.01.14 |
申请人 |
AKZO N.V. |
发明人 |
CAIRNS, JAMES;LOGAN, ROBERT T.;MCGARRY, GEORGE;ROY, ROBERT G.;WOODS, GILBERT F. |
分类号 |
A61K31/57;A61K31/575;A61P29/00;C07J9/00;C07J31/00;C07J41/00;(IPC1-7):A61K31/56;C07J5/00 |
主分类号 |
A61K31/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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