发明名称 |
Steroid hormone-antitumor derivatives |
摘要 |
A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula <IMAGE> wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C1-C4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of -O-, -COO-, -CONH-, -NH- or <IMAGE>
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申请公布号 |
US4260736(A) |
申请公布日期 |
1981.04.07 |
申请号 |
US19790062819 |
申请日期 |
1979.08.01 |
申请人 |
KUREHA KAGAKU KOGYO KABUSHIKI KAISHA |
发明人 |
ASANO, KIRO;TAMURA, HUMIO;TANAKA, HIROMITSU;ENOMOTOL, SATORU |
分类号 |
C07J1/00;C07J41/00;C07J43/00;(IPC1-7):C07J43/00 |
主分类号 |
C07J1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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