Antidiabetic sulphonyl ureas and sulphonyl

摘要

Sulphonyl ureas and -semicarbazides of (I) X = -O or -S, satd. or unsatd., straight- or branched alkylene group (C1 - C3); oxymethylene, thiamethylene, thiaethylene, opt. alkylated or acylated iminomethylene, opt. alkylated carboximido or a valency bond. R1 = H, halogen, alkyl, alkoxy or CF3; Y = satd. or unsatd., straight- or branched alkylene (C1 - C6) which may contain an N- or -O atom; Z = straight- or branched alkylene (C1 - C4); R2 = satd. or unsatd., straight- or branched alkyl- or cycloalkyl residue opt. interrupted by S or O or containing an endoalkylene group, opt. substd. aryl or aralkyl residue or opt. substd., satd. or unsatd. alkylene imino residue (C3 - C7) which may contain an endoalkylene group (I) have anti-diabetic activity.