| 摘要 |
NEW MATERIAL:Title compounds of formula I (n is integer of 1-4; a, b are H or a bond between a and b is formed; R1, R2 are H, lower alkyl, phenyl, or they may form 5- or 6-membered heterocyclic ring together with the adjacent nitrogen atom). EXAMPLE:3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraene amide. USE:Treatment for hepatic disorders: they are of low toxicity and show ameliorative and pyrophylactic effects on hepatic disorders. PREPARATION:The Wittig's reagent that is derived from a compound of formula III (X is halogen) is made to act on a compound of formula II to give the compound of formula I. The Wittig's reagent is, e.g., a compound of formula IV (R is alkyl), which is derived from a compound of formula III and trialkyl phosphite. In the reaction, a basic reagent such as butyllithium is added in general. |
