PROCEDIMIENTO PARA PREPARAR NUEVAS 1-(AMINOALQUILAMINO)-5,8-DIHIDROXI-4-SUSTITUIDO-ANTRAQUINONAS.

摘要

There are provided 1-(aminoalkylamino)-5,8-dihydroxy-4-substituted; anthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors, of the formula: …… wherein Z is hydroxy or monoalkylamino having up to 3 carbon atoms; Q is a divalent moiety selected from the group consisting of those of the formulae: …… wherein n is an integer from 2 to 4, inclusive; R1 and R2 are each individually selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms, monohydroxyalkyl having from 2 to 4 carbon atoms and wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group, dihydroxyalkyl having from 3 to 6 carbon atoms and wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group, formyl, alkanoyl having from 2 to 4 carbon atoms, trifluoroacetyl and moieties of the formulae: …… wherein n is an integer from 2 to 4, inclusive, R is alkyl having from 1 to 4 carbon atoms, and R3 and R4 are each individually selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms, and monohydroxyalkyl having from 2 to 4 carbon atoms and wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group, and R3 and R4 taken together with their associated N(itrogen) is morpholino, thiomorpholino, piperazino, 4-methyl-1-piperazino or a moiety of the formula: …… wherein m is an integer from 2 to 6, inclusive; with the proviso that the ratio of the total number of carbon atoms to the sum of the total number of oxygen atoms plus the total number of nitrogen atoms in the side chains at the 1-position may not exceed 4; and the corresponding leuco bases and tautomers thereof; and the pharmacologically acceptable acid-addition salts thereof.