| 摘要 |
NEW MATERIAL:Antibiotic B-41D of the formula. Appearance: amorphous powder. Elementary analysis (%): C, 71.40; H, 8.82; O, 20.22. Molecular weight: 556. Solubility: soluble in n-hexane, acetone, ethanol, etc.; sparingly soluble in water. USE:An acaricide and an anthelminthic agent and repellent more active than compound B-41, particularly B-41A3 and B-1A4. PROCESS:A strain of Streptomyuces B-41-146 (FERM-P No.1,438) is incubated in a liquid culture medium aerobically. The culture thus obtained is filtered, and the filter cake is extracted with methanol. Water is then added to the extract, and extracted with n-hexane. The extract is concentrated in vacuo, and adsorbed on columns of silica gel (Wakogel C-200 ) and Sephadex LH-20 (manufactured by Pharmacia) in the order mentioned, and eluted with a suitable solvent to collect a fraction containing the titled compound which is then concentrated and recrystallized to afford the compound of the formula. |
