| 摘要 |
Novel compounds, dibenzo[a,d]cycloheptene derivatives, of the general formula <IMAGE> (I) wherein R1 represents a hydrogen atom, a halogen atom or a lower alkyl group, R2 and R3 each represent a hydrogen atom or a lower alkyl group, and Z represents a group of the formula <IMAGE> These novel compounds are useful as non-steroidal anti-inflammatory agents free from gastrointestinal lesions. The compounds of formula (I) can be prepared, for example, by cyclizing a compound of the general formula <IMAGE> (II) wherein R1 and R2 are as defined above, X represents a hydroxyl group or a halogen atom, one Y represents a group of the formula -CH2COX and the other Y represents a hydrogen atom; optionally hydrolyzing the cyclized product; and optionally esterifying the product, and/or etherifying its enol group. |
