Two-layer antibacterial tablets - contg. precursors of mecillinam and ampicillin in separate layers

摘要

Antibacterial tablets comprise a 1st layer contg. a precursor (I) for 6-((hexahydro-1H-azepin-1-yl)methylenamino)penicillanic acid (mecillinam) and a 2nd layer contg. a precursor (II) for 6-(D-alpha-aminophenyl -acetamido)penicillanic acid (ampicillin). (I) and (II) are pref. readily hydrolysable esters, esp. pivaloyloxymethyl 6-((hexahydro-1H-azepin-1-yl) methylenamino) penicillanate hydrochloride (Ia) and pivaloyloxymethyl 6-(D-alpha-aminophenylacetamido) penicillanate (IIa). The tablets have good stability and disintegrate readily to provide rapid release of (I) and (II).