Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them.

摘要

Acompoundoftheformula(I):
or a pharmaceutically acceptable ester, amide or salt thereof wherein R, is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methyl-sulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R₂ is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl group; R₃ is a hydrogen, chlorine or bromine atom or a hydroxyl group; R. is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R, is a hydrogen atom or a methyl group; R₆ is a hydrogen atom or a methyl group; R₇ is a hydrogen atom or a methyl or ethyl group; R₈ is a hydrogen atom or a methyl or ethyl group; X is an oxygen atom or a bond, and Y is an alkylene group of up to 5 carbon atoms, or a bond has been found to possess anti-obesity and/or anti-hyperglycaemic activity.