| 摘要 |
<p>1-p-Aminoalkoxy phenyl-1-p-hydroxyphenyl-2-phenylalk-1-ene derivatives of the formula:… …<CHEM>… R1 = H, lower alkyl… R2 = lower alkyl… or R1 and R2 forms a heterocyclic radical with the adjacent N-atom… R3 = halogen or lower alkyl… R4 = H, halogen, OH, lower alkyl or forms with the benzene ring a naphthyl radical… n = 2, 3, 4, 5, 6… Possess anti-oestrogenic activity and are useful in the treatment of anovulatory infertility and of breast tumours. Representative of the compounds is I-(p-ss-dimethylaminoethoxyphenyl)-trans-I-p-hydroxyphenyl-2-p-tolylbut-I-ene.</p> |
