| 摘要 |
Disclosed are antibiotic cephalosporins (I) of the formula: <IMAGE> I Wherein the stylized radical attached to the 7-amino nitrogen of the cephalosporin moiety represents a nitrogen-containing heterocyclic group (mono- or polycyclic); R is, inter alia, hydrogen, alkyl, heterocyclylalkyl, aryl, alkenyl, aralkyl, -NR2, -OR, COOR, CONR2 or CN; A is conventionally known in the cephalosporin art; and R2 is H, or loweralkoxyl; X is O, CH2, or NR7 (R7 is, inter alia, hydrogen, alkyl or aralkyl. Also disclosed are the pharmaceutically acceptable salt and ester derivatives of I; processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
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