| 摘要 |
<p>CONL-35 THIAZOLINEAZETIDINONE DERIVATIVES Thiazolineazetidinone derivatives of the formulae 1,2,and 3. 2 3 wherein R is derived from the commonly known carboxamido groups present in penicillins, R1 is a carboxy protecting group commonly used in penicillin chemistry, and R2 is Cl, Br, I, CN, lower alkoxy, lower acyloxy, SCN, SCH3, S-phenyl, S-heteroaryl such as 5-mercaptotetrazole or 2-mercapto-5-methyl-1,3,4-thiadiazole, NO3, N3, NHphenyl, and N(CH3)2 with the proviso that R2 in the compounds of formula 1 is limited to Cl, Br, I, and lower acyloxy, and a process for preparing said compounds from 2-(substituted methyl) penicillin sulfoxides followed by treatrnent with a base. The compounds of formulae 1,2,and 3 are useful as intermediates in the synthesis of cephalosporins.</p> |
