| 摘要 |
The invention concerns new analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives of the formula: <IMAGE> I in which R1 is an optionally substituted phenyl, phenyl- (1-4C)alkyl, naphthyl, monocyclic or bicyclic heteroaromatic or (monocyclic or bicyclic heteroaromatic)- (1-4C)alkyl radical, R2 is a (3-8C)cycloalkyl, [(3-8C)cycloalkyl]-(1-4C)alkyl or (3-6C)alkenyl radical, or an optionally substituted phenyl or phenyl- (1-4C)alkyl radical, and R3 is a (1-4C)alkyl radical, preferably a methyl radical; together with pharmaceutically acceptable salts thereof. Also provided are processes for the manufacture of, and pharmaceutical compositions of, derivatives of formula I and salts thereof. Some of the derivatives of formula I possess anti-inflammatory properties and/or are inhibitors of the enzyme prostaglandin synthetase in addition to possessing analgesic properties. A typical compound of the invention is 3-(thien-2-yl)-6-[(N-acetyl)isobutylamino]tetrahydro-1,3,5-triazine-2, 4-dione.
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