| 摘要 |
Zinc complexes of various monovalent and divalent polyether antibiotics are provided which act as coccidiostats and growth promoting agents when administered to food- producing animals such as cattle, sheep, swine and poultry. Soluble zinc salt is added to a fermentation beer containing the polyether antibiotics to form an insoluble, recoverable biomass containing the desired zinc antibiotic complex. The subject zinc complexes of polyether antibiotics may be administered in feed compositions and feed additive compositions, or as implants. The polyether antibiotics which may be used to make the subject zinc complexes include: linear monovalent and divalent polyethers (e.g. monensin, nigericin, lasalocid, lysocellin); non-glycolic monovalent monoglycoside polyethers (septamycin, dianemycin, lenoremycin, carriomycin and antibiotic A-204); mononitrogen- containing divalent pyrrole ethers (e.g. calcimycin, X- 14547); polynitrogen-containing divalent pyrrole ethers (e.g. A- 23187); glycolic monovalent monoglycoside polyethers (e.g. etheromycin); and other polyether antibiotics including ionomycin, aabomycin, disnerycin, duamycin, BL-580, K- 41, SF-1195, M-4164A, A-32887, 30,504RP, 38,986, 44,161, 47,433, 47,434 and 47,224. The above zinc complexes are active agents for improving cardiovacular function in animals. |
