UN PROCEDIMIENTO PARA LA PREPARACION DE ESPIRO-QUINOLILLUDANTOINAS, UTILES COMO INHIBIDORES DE LA ALDOSA-REDUCTASA PARA EL TRATAMIENTO DE LAS COMPLICACIONES CRONICAS DE LA DIABETES

摘要

Novel spiro-quinolylhydantoin derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. Preferred compounds include spiro[imidazolidin-4,4'-pyrano[3,2-h]quinolin]-2,5-dione and spiro[imidazolidin-4,4'-pyrano[2,3-f]quinolin]-2,5-dione.