| 摘要 |
Pentaerythritol tetranicotinate (I) was prepd. by reaction of pentaerythritol (II) with nicotinic acid (III) in the presence of arenesulfonic acids or alkanesulfonic acids. The ester I is useful as a anticholesteremic and coronary vasotonic agent (no data). Thus, a mixt. of II 1.36, III 6.15, and PhSO3H/H20 19.46 g in C6H6 was refluxed 42 hr. with removal of H2O to give 92.4% I. p-MeC6H4SO3H/H2O and MeSO3H were also used in place of PhSO3H.
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