Novel 15-deoxy-16-ethynyl and -16-(1-propynyl)-1-carboxy and 1-carbinol prostaglandins of the A, D, E and F series

摘要

The invention described herein relates to novel 15-deoxy-16-hydroxy-16-ethynyl or 16-(1-propynyl) prostaglandins of E, F, D and A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: <IMAGE> wherein R1 is selected from the group consisting of hydrogen and C1-C6 alkyl; R15 is selected from the group consisting of C1-C4 alkyl, di-C1-C4-alkylamino, phenyl and phenyl substituted with one or more substituents selected from the group consisting of C1-C4 alkyl, OR, SR, F or Cl, wherein R is an alkyl group.