| 摘要 |
Novel penicillins of the formula+q,10 WHEREIN C ¦ A¦ C represents a substituted or unsubstituted benzene or nitrogen atom-containing heteroaromatic ring which may be substituted, C ¦C ¦ CB represents a pyridine, pyrazine or pyridazine ring, X represents an oxygen or sulfur atom, Y represents a hydrogen atom or a loer alkoxycarbonyl or lower alkanoyl group, and R1, R2 and R3 are each a hydrogen or halogen atom or a nitro, lower alkylamino, di(lower)alkylamino, aine, lower alkoxycarbonylamino, lower alkanoylamino, amino(lower)alkyl, lower alkyl, lower alkoxy, hydroxyl, sulfamoyl, trifluoromethyl, lower alkylthio or lower alkylsulfonyl group, excluding the cases where all of R1, R2 and R3 are hydrogen atoms and where R1 is a hydroxyl group and R2 and R3 are each a hydrogen or halogen atom, and their nontoxic, pharmaceutically acceptable salts, which can be prepared by reacting a carboxylic acid of the formula: X-Y ¦ C¦ ¦C-COOH A¦ CB wherein C C ¦ ¦C A¦ ¦ C , CB, X and Y are each as defined above or its reactive derivative with a compound of the formula:+q,21 WHEREIN R1, R2 and R3 are each as defined above or its reactive derivative, and are ueful as antimicrobial agents against gram-positive and gram-negative bacteria including Pseudomonas. |
