| 摘要 |
<p>1-(4-Cyano-4-aryl)cyclohexyl- 4-carboxypiperidine derivs. of formula (I) and their acid-addn. salts are new. R1 is H or 1-6C alkyl; x is an opt. double bond; R is OH, 1-6C alkoxy, aryl-(1-6C)alkoxy, aryloxy-(1-6C)alkoxy, (1-6C)alkoxy-(1-6C)alkoxy, 1-6C aminoalkoxy, mono- or di-(1-6C)alkylamino-(1-6C)alkoxy, 1-pyrrolidinyl-, 1-piperidinyl- and 4-morpholinyl-(1-6C)alkoxy, NH2, aryl-(1-6C)alkylamino, mono- or di-(1-6C)alkylamino, 1-pyrrolidinyl, 1-piperidinyl or 4-morpholinyl; and Ar' and Ar'' are aryl, thienyl or pyridinyl. The term aryl used above is Ph opt. substd. by 1-3 halogen, 1-6C alkyl, 1-6C alkoxy, NO2, NH2, CN, COOH, (1-6C)alkoxycarbonyl, mono- or di-(1-6C)alkylamino- carbonyl or CF3. Cpds. (I; x is absent) are potent antihistaminic agents and (I; x is double bond) are intermediates in their prepn.</p> |
