发明名称 |
PROCEDEU PENTRU PREPARAREA UNOR 1,4-DIHIDROPIRIDINCARBOXILATI DE ARALCHIL |
摘要 |
<p>1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1,2 and 6-positions are coronary dilating, spasmolytic and hypotensive agents. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbobenzoxy-1,4-dihyd ropyridine is a representative embodiment, are prepared through the reaction of an ylidene- beta -dicarbonyl compound, which may be generated in situ from the corresponding beta -dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a beta -dicarbonyl compound and an amine.</p> |
申请公布号 |
RO68479(A) |
申请公布日期 |
1981.01.30 |
申请号 |
RO19760084916 |
申请日期 |
1976.02.25 |
申请人 |
BAYER AG,DE |
发明人 |
BOSSERT,FRIEDRICH,DE;WEHINGER,EGBERT,DE;STOEPEL,KURT,DE;VATER,WULF,DE;KAZDA,STANISLAV,DE |
分类号 |
C07D211/02;A61K31/4427;A61K31/455;A61P9/08;A61P9/12;C07D211/90;C07D401/04;(IPC1-7):07D211/84 |
主分类号 |
C07D211/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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