| 摘要 |
Schistosomicidal compositions containing a compound of the formula:- …<CHEM>… wherein R<1> and R<2> each hydrogen, C1-C4 alkyl, hydroxy-C1-C4 alkyl, or C3-C6 cycloalkyl;… R<3> is nitro, cyano, fluorine, chlorine, bromine or iodine,… and R<4> is methyl or hydroxymethyl;… or a pharmaceutically acceptable acid addition salt thereof;… and a compound of the formula:- …<CHEM>… wherein R is cyclohexyl, 3-cyclohexenyl, 4-pyridyl, phenyl, 2-fluorophenyl or 4-aminophenyl, with or without a pharmaceutically acceptable diluent or carrier. Preferably, compound (I) is oxamniquine and compound (II) praziquantel. The compositions are unexpectedly active due to synergism. …<??>Also described are methods of treating Schistosomiasis by the concomitant administration of compounds (I) and (II). |
