PROCESS FOR THE PREPARATION OF 1-OXA-1-DETHIA-CEPHALOSPORIN DERIVATIVES AND NEW INTERMEDIATES COMPOUNDS THEREFOR

摘要

7-Acylamino-2-alkyl-1-oxa-1-dethia-3-cephem derivs. of formula (I) and their salts and esters are new. In (I), R is R1CH(R2)-[R1=2- or 3-thienyl; R2=H or carboxyl or a gp. of formula (II)[R3=H, lower alkyl or carboxyl lower alkyl; R4 is H or methoxy; R5 is lower alkyl; R6 is tetrazolyl thiomethyl or methylterazolyl thiomethyl. (I) are useful as broad spectrum antibacterials.