PROCESS FOR PRODUCING TERMINALLY BIFUNTIONAL XYLITE DERIVATIVES OF CITOSTATIC ACTIVITY

摘要

Xylitol derivatives of the general formula wherein R<1> and R<5> are the same and represent halogen, tosyloxy or mesyloxy, in which case R<2> and R<4> represent hydroxy or R<1> and R<2> as well as R<4> and R<5> together form oxygen bridges, R<3>, whatever the values of R<1>, R<2>, R<4> and R<5>, is hydrogen, alkanoyl, aralkanoyl or aroyl, exhibit cytostatic activity. They can be prepared from xylitol by standard methods. The compounds can be formulated for pharmaceutical use in conventional manner.