PROCESS FOR THE ISOLATION OF ALKALOID COMPONENTS FROM THE PLANT VINCA ROSEA L.

摘要

There is disclosed a new process for the isolation of alkaloid components from the plant Vinca rosea L. More particularly, the invention relates to a process for the large-scale isolation of native catharantine, vindoline and 3',4'-anhydrovinblastine whereby the isolation of vincristine, vinblastine, leurosine and the corresponding dosacetoxy, desacetyl and N-desmethyl derivatives in a manner known per se can also be accomplished. The alkaloids isolated according to the invention possess valuable biological activities, leurosine for instance has tumour inhibiting activity and the Ndesmethyl-N-formyl derivative thereof is one of the most promising substances in the fight against leucemia.