| 摘要 |
Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from L-aspartic acid via intermediates II und III: <CHEM> wherein R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group; R<6> and R<7> are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; R<1> min is hydrogen or a protecting group; and R<a>, R<b> and R<c> are independently selected from alkyl, aryl and aralkyl. |
